This second screening campaign aims to discover new classes of antimicrobial agents for treating multi-resistant infections
Under the terms of the partnership, Inra grants Nosopharm exclusive access to around 100 unique strains of Photorhabdus and Xenorhabdus. The DGIMI laboratory has the most extensive collection in the world of strains for these two genera of bacteria. When applying its innovative, proprietary methods to the strains in order to discover new bioactive compounds, Nosopharm will capitalize on experience gathered during the first screening campaign.
The aim of this campaign is to discover a new and innovative systemic antimicrobial agent targeting gram-negative pathogens, including Pseudomonas aeruginosa, as well as a new systemic novel antifungal agent targeting Candida spp pathogens.
- Three patent applications covering three new classes of antimicrobials (EP2468718, WO2012085177, WO2016046409)
- Three articles published in peer-reviewed journals (The Journal of Antibiotics, 2013, Genome Announcements, 2014, Molecular Cell, 2018)
- An oral presentation at the 54th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC)
- The discovery of a new class of antibiotics – odilorhabdins – now at the preclinical stage for the treatment of multidrug-resistant Enterobacteriaceae infections. This new class has been selected to be part of the European ND4BB ENABLE consortium.
“Bacteria of the genera Xenorhabdus and Photorhabdus are insect pathogens and nematode symbionts; today they are also recognized for their marked ability to produce many bioactive molecules with antimicrobial activity (antibacterial and antifungal). Since the 1980s, our laboratory (DGIMI-UMR Inra-UM1333) has nurtured a collection of these bacteria, which now comprise 650 strains, originating over the five continents. Since 2016, this collection has been associated with the ‘environment’ pillar of the center RARe – Agronomic Resources for Research,” said Alain Givaudan, deputy director of Inra’s DGIMI unit. “With Nosopharm, we are prioritizing research into small molecules of natural origin. The molecules are biosynthesized within the bacteria thanks to large enzyme complexes (called ‘nonribosomal peptide synthetases’ or ‘NRPS’), which are true biological microfactories with unusually long genes by design and are prominent in the Xenorhabdus and Photorhabdus genomes.”