In the history of cancer treatment, the main idea was initially to have one approach, using one method or treatment agent. After this concept, the approach became a bit more multilevel and then the treatment was considered under the concept of surgery, radiation or chemotherapy. Unfortunately, despite this change in the concept of the treatment, the clinical outcome is still poor since the overall survival or response rate hasn’t changed dramatically. This article by Ioannis Papasotiriou from RGCC will try to propose possible options that may be added to the present concept or become standalone alternatives to cancer treatment based on cancer physiology and the latest developments in molecular oncology, as well as in molecular and cellular biology.