Current Edition

The Rabbit and the Horseshoe Crab

The LAL method, which is the industry standard for the detection of gram-negative bacterial endotoxin, was preceded by the rabbit pyrogen test by about 30 years. To understand the benefits of current testing, as well as the industry’s shift from the rabbit to Limulus polyphemus or the Atlantic horseshoe crab, it is important to follow the path through which testing has evolved. Lisa Komski at FUJIFILM Wako Chemicals U.S.A. Corporation outlines what steps need to be taken next.