External demands from regulators and the wider market are evolving at an accelerating pace, which is challenging life sciences firms’ ability to respond. Project cycles of 12–24 months are no longer practical, especially given that new or updated requirements may have entered the frame along the way. In this article, Romuald Braun at Amplexor discusses the need for greater responsiveness from IT teams and suppliers to the changing needs of the business and how they might achieve that.