Bayer and Hurdle have published ground-breaking research that represents a great advancement in aging research. The research introduces and validates a novel saliva-based DNA methylation biomarker designed to quantify systemic chronic inflammation (SCI), that the researchers have named, InflammAge. This innovative approach provides a non-invasive method for quantifying and tracking inflammation-related epigenetic biomarkers associated with aging.
The study, titled “A novel framework to build saliva-based DNA methylation biomarkers: Quantifying systemic chronic inflammation as a case study,” was conducted by a collaborative team of scientists from Hurdle, Bayer’s Consumer Health Division, and leading academic institutions, including the University of Birmingham and the University of Edinburgh. The research demonstrates how InflammAge can effectively help people quantify and assess the biological processes of aging, offering a reliable and non-invasive alternative to existing blood- or other tissue-based methods of measuring aging at the cellular level.
As increased age is a significant risk factor for chronic diseases such as cardiovascular disease, cancer, and neurodegenerative disorders, the ability to measure biological aging through a simple saliva test has the potential to guide and revolutionize preventative healthcare. The research, conducted on a cohort of more than 18,000 individuals known as Generation Scotland, highlights the strong association between the InflammAge biomarker and various health outcomes, including all-cause mortality, lifestyle factors, and the likelihood of developing age-related diseases. Notably, in many cases, InflammAge outperforms traditional blood markers such as C-reactive protein (CRP) in predicting long-term health risks.
Dr. Daniel Martin-Herranz, Chief Science Officer and Co-founder at Hurdle, stated, “Our AI-powered multi-omics biomarker discovery engine has made it possible to translate complex biological data into actionable health insights. InflammAge represents a complete shift in how we measure and understand chronic inflammation. By developing a robust, saliva-based biomarker, we are not only advancing precision medicine but also making cutting-edge science accessible for preventative health.”
“As the global population ages, it becomes increasingly important to better understand and reliably quantify ageing at the biological level,” said Veronika Óvári, Global Senior Medical Manager, Consumer Health division of Bayer. “We are excited that through InflammAge a simple, non-invasive, saliva test could revolutionize self-care and how people can manage their aging journey.”
The study also indicates that lifestyle factors, including smoking and alcohol consumption, are significantly associated with InflammAge acceleration, while healthy eating patterns, such as regular consumption of oily fish, with InflammAge deceleration. This finding underscores the importance of lifestyle modifications in managing chronic inflammation and promoting overall health.
Professor Janet M Lord FMedSci, CBE, further highlighted the significance of InflammAge: “There are many biomarkers that relate to biological aging. InflammAge is novel in that it relates to one of the hallmarks of aging, namely inflammation. Changes in this biomarker will therefore give information on factors driving any acceleration in biological age, allowing therapeutic interventions to be developed.”
Professor Riccardo E. Marioni, Professor of Molecular Epidemiology of Ageing at the Centre for Genomic and Experimental Medicine, University of Edinburgh, emphasized the advantages of saliva-based testing: “Saliva samples can be easily provided at home, making them ideal for remote health monitoring. Here, we show how epigenetic patterns from saliva can be used to capture information about inflammation, a key risk factor for multiple diseases.”
