New technologies allow for direct patient care and necessitate an overhaul in the focus of healthcare industry business models. It is becoming clear that in order to stay relevant in the future healthcare ecosystem, pharma companies must look to business models that foster much more direct patient engagement than previously. New methods offer significant potential in increasing the quality and efficiency of care. Digital health solutions could therefore solve the major long-term issues of pharma’s most important client groups – patients, providers and payers – all at the same time. Ulrica Sehlstedt, Nils Bohlin, Fredrik de Maré and Richard Beetz at Arthur D. Little describe how digital is reshaping the pharma arena.