Are murine in vivo models helpful as disease models for drug development? In at least two important therapeutic areas, oncology and allergy, the value of mouse models is, at the very least, questionable. Dr G.C. Mudde of S-TARget therapeutics GmbH outlines how, in the last decades, the need for human-specific animal models has been realised and accepted by official regulatory authorities; several centralised primate research facilities are now available for testing human-specific drugs, but more money and effort should go into understanding the differences and similarities between the two species.
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