High-energy media milling (nanomilling) has become an increasingly popular drug delivery technique and for good reason; it is suitable for oral, injectable, topical, and inhalable applications. Rob Lee at the CDMO division of LLS Health shows how for complex solid drug products of all kinds, nanomilling continues to prove its viability as an efficient, reliable and validatable approach to enhancing the bioavailability of poorly water-soluble active pharmaceutical ingredients (APIs), as well as minimising undesired side-effects.