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Impact of Sterilisation Method on Packaging Component Machinability Performance: Steam vs. Gamma Evaluation of the 1ml Long Plunger

The machinability of parenteral packaging components is recognised to have a significant influence on productivity of the drug product manufacturing process. As Simon Côté of West Pharmaceutical Services explains, there are various processes that can be used for washing and sterilising elastomers for aseptic fill, and depending on conditions of processing, the physical and functional characteristics of the component will be altered to some degree. In this case study, elastomeric components intended for aseptic processing are considered with respect to machinability on a lab-scale filling line.