Patient recruitment challenges the drug development process for a number of reasons. Elio Evangelista at Cutting Edge Information discusses why the increased demand for clinical trial patients, combined with the relatively flat growth in clinical investigators and study sites, places the pharmaceutical industry in a predicament.
https://international-pharma.com/wp-content/uploads/2013/04/Patient-Recruitment-The-Most-Recognized-Silent-Driver-of-Clinical-Development-Costs.pdf