Current Edition

Revisited Cell Cultures and Valuable Methods for Pre-clinical Studies

During the last ten years, the development of transgenic techniques has rendered possible the creation of mutant strains of rodents mimicking human diseases and the assessment of the role of biochemical lesions in their development. However, maintaining and expanding colonies of transgenic rodents is time-consuming, expensive and above all, the characterisation (phenotyping) of these new animals needs highly experienced people. Pr. Philippe Poindron of Neuro-Sys looks into the development of alternative methods for studying efficiency and mode of action of new compounds in preliminary preclinical studies.….pdf