From the perspective of the thermal packager it has always been best to assume that whatever can go wrong will go wrong, and that however simple and user-proof the packaging, people will still find a way to do something bizarre with it. Katie Friday of Tower Cold Chain Solutions argues that the advent of the new guidelines is therefore to be welcomed, since they place a very considerable onus on all parties to comply with what are largely well-thought-out and sensible provisions. Beyond this, potentially, they spell an end to a period of significant frustration.
https://international-pharma.com/wp-content/uploads/2014/10/Thermal-Packaging.pdf